Dynamine (Methylliberine)
Only three human RCTs have tested methylliberine. The only one measuring cognition with methylliberine alone (La Monica et al., 2023, n=25, 100mg/day) found better self-rated concentration, motivation, mood and energy, but a negligible effect on objective cognitive tests (Stroop, Trail Making B). A 4-week safety trial (VanDusseldorp et al., 2020, n=125, 100–150mg/day) found no clinically significant cardiovascular or blood changes; it did not test cognition. A third trial (Cintineo 2022) tested it only inside a caffeine + theacrine combination. Both methylliberine-specific trials were funded in whole or part by Compound Solutions, which sells Dynamine, and a La Monica co-author holds patents on methylliberine.
Evidence reviewed:
Mechanism of action
Dynamine (methylliberine) is a purine alkaloid found in kucha tea leaves, structurally related to caffeine and theacrine. It is described as blocking adenosine receptors (like caffeine) and inhibiting phosphodiesterase. In a 4-week trial at 100–150mg/day it produced no clinically significant changes in heart rate, blood pressure or blood biomarkers. No study has measured tolerance.
Clinical evidence summary
Only three human RCTs have tested methylliberine. The only one measuring cognition with methylliberine alone (La Monica et al., 2023, n=25, 100mg/day) found better self-rated concentration, motivation, mood and energy, but a negligible effect on objective cognitive tests (Stroop, Trail Making B). A 4-week safety trial (VanDusseldorp et al., 2020, n=125, 100–150mg/day) found no clinically significant cardiovascular or blood changes; it did not test cognition. A third trial (Cintineo 2022) tested it only inside a caffeine + theacrine combination. Both methylliberine-specific trials were funded in whole or part by Compound Solutions, which sells Dynamine, and a La Monica co-author holds patents on methylliberine.
Human effect matrix
Based on human clinical trials only. Animal and in-vitro data excluded.
| Effect | Evidence | Magnitude | Studies |
|---|---|---|---|
| Subjective Energy | preliminary | Moderate | 1 |
| Focus & Motivation | mixed | Small | 1 |
| Cardiovascular Safety | moderate | Negligible | 1 |
Evidence key: Strong = multiple consistent RCTs · Moderate = smaller/fewer RCTs · Preliminary = early trials or small n · Mixed = conflicting results
Documented benefits
- Better self-rated energy, mood and motivation (one small RCT)
- No clinically significant heart rate or blood pressure change over 4 weeks at 100–150mg
Side effects & cautions
- Limited safety data: three human RCTs, both methylliberine-specific trials funded by the manufacturer
- Objective cognition: no measurable effect on Stroop or Trail Making tests in the only trial that tested it
- Mild GI discomfort possible
- Possible interaction with caffeine (additive stimulation)
- Not recommended during pregnancy (precautionary: no pregnancy data)
How to take
Stacking recommendations
Ingredients that pair well with Dynamine (Methylliberine) and why.
A common pairing in pre-formulated stacks. In tactical personnel, 150mg caffeine + 100mg methylliberine + 50mg theacrine matched 300mg caffeine on vigilance reaction time with a smaller diastolic blood pressure rise (Cintineo 2022) — but that tests the combination, not Dynamine alone.
L-Theanine is commonly paired with stimulants for calmer focus, though in a controlled caffeine trial it did not significantly reduce jitteriness, and the combination with Dynamine has not been tested.
Dynamine provides acute adenosine blockade; Zynamite extends dopamine via COMT inhibition. Together found in Thesis blends for multi-pathway stimulation.
Frequently asked questions
How is Dynamine different from caffeine?
It is a related purine alkaloid, but its evidence base is far thinner: three small human RCTs versus decades of caffeine research. In a 4-week trial at 100–150mg/day it caused no clinically significant heart rate or blood pressure change, and in the one cognition trial it improved self-rated energy and mood but not objective test performance. No trial has compared its onset, duration or sleep effects head-to-head with caffeine.
Does Dynamine build tolerance like caffeine?
Unknown. No study has measured tolerance to methylliberine; the 4-week trial measured safety markers, not whether effects fade. Claims of "minimal tolerance" are not supported by any published trial.
Can I buy Dynamine on its own?
Not easily. Dynamine (methylliberine) is a trademarked ingredient from Compound Solutions and is primarily available in pre-formulated stacks (e.g., Thesis nootropics). Standalone Dynamine capsules are rare on the consumer market.
Is it safe to combine Dynamine with caffeine?
Yes — this is a common combination in performance supplements. Since both block adenosine, the stimulant effects are additive. Keep total combined caffeine + Dynamine intake moderate and monitor for overstimulation (anxiety, restlessness). Start with low doses of each.
Top stacks containing Dynamine (Methylliberine)
Dynamine (Methylliberine) in Southeast Asia
Products in Southeast Asia
HSA / NPRA / BPOM / FDA PH / Thai FDA
SEA country guides
Regulatory note
Health supplements in Singapore are regulated by the Health Sciences Authority (HSA); in Malaysia by the National Pharmaceutical Regulatory Agency (NPRA); in Indonesia by the Badan Pengawas Obat dan Makanan (BPOM); in the Philippines by FDA Philippines; in Thailand by FDA Thailand. Halal certification is required by law for supplements marketed to Indonesian consumers from 18 October 2026, regulated by the Badan Penyelenggara Jaminan Produk Halal (BPJPH); in Malaysia, products described as halal must be certified, with the Jabatan Kemajuan Islam Malaysia (JAKIM) as the certifying body. We surface certification status per product where verifiable. This page is editorial, not medical advice. Consult a qualified healthcare professional before starting any supplement.
Sources (3)expand
- PMID 37960163Methylliberine Ingestion Improves Various Indices of Affect but Not Cognitive Function in Healthy Men and Women (2023)
- PMID 32121218Safety of Short-Term Supplementation with Methylliberine (Dynamine) Alone and in Combination with TeaCrine in Young Adults (2020)
- PMID 36016763Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial (2022)